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This methylation profile is now obtained for the MBL stage3 and continues to be somewhat steady after a while. Nonetheless, some CLL have intratumor variability in particular regions, which can alter the expression of several genes and aid tumor evolution.seventy one Of Notice, this variability is larger in U-CLL than in M-CLL which is related to escalating variety of subclones.7,71
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mutations and complicated kar yotype. It follows a linear evolution in the CLL clone in the recurrent acquisition of CDKN2A
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